NMNAT1 (NM_022787) Human Recombinant Protein
Product Specifications
Background
This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD) . The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]
Overview
Recombinant protein of human nicotinamide nucleotide adenylyltransferase 1 (NMNAT1)
Synonyms
LCA9; NMNAT; PNAT1; SHILCA
Gene ID
64802
UniProt
Q9HAN9, A0A024R4E1
Accession Number mRNA
NM_022787
Chromosomal Location
1p36.22
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Nicotinate and nicotinamide metabolism
Field of Research
Metabolic pathways, Nicotinate and nicotinamide metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
31.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NMNAT1
Species
Human
Protein ID
NP_073624
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/64802
Uniprot URL
https://www.uniprot.org/uniprot/Q9HAN9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022787
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_073624
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