ALDH4A1 (NM_170726) Human Recombinant Protein
Product Specifications
Background
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009]
Synonyms
ALDH4; P5CD; P5CDh
Gene ID
8659
UniProt
P30038, A0A024RAC7
Accession Number mRNA
NM_170726
Chromosomal Location
1p36.13
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways
Field of Research
Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
59 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ALDH4A1
Species
Human
Protein ID
NP_733844
Overview
Recombinant protein of human aldehyde dehydrogenase 4 family, member A1 (ALDH4A1), nuclear gene encoding mitochondrial protein, transcript variant P5CDhS
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8659
Uniprot URL
https://www.uniprot.org/uniprot/P30038
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_170726
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_733844
Curated Selection
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