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Endothelin B Receptor (EDNRB) (NM_000115) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Overview

Recombinant protein of human endothelin receptor type B (EDNRB), transcript variant 1

Synonyms

ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB; HSCR; HSCR2; WS4A

Gene ID

1910

UniProt

P24530

Accession Number mRNA

NM_000115

Chromosomal Location

13q22.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction

Field of Research

Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, GPCR, Transmembrane

Molecular Weight

46.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

EDNRB

Species

Human

Protein ID

NP_000106

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1910

Uniprot URL

https://www.uniprot.org/uniprot/P24530

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000115

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000106

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