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MPST (NM_021126) Human Recombinant Protein

Product Specifications

Background

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU) . Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human mercaptopyruvate sulfurtransferase (MPST), nuclear gene encoding mitochondrial protein, transcript variant 1

Synonyms

MST; TST2; TUM1

Gene ID

4357

UniProt

P25325

Accession Number mRNA

NM_021126

Chromosomal Location

22q12.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cysteine and methionine metabolism, Metabolic pathways

Field of Research

Cysteine and methionine metabolism, Metabolic pathways

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

35.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

MPST

Species

Human

Protein ID

NP_066949

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4357

Uniprot URL

https://www.uniprot.org/uniprot/P25325

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_021126

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_066949

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