INSIG2 (NM_016133) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]
Synonyms
INSIG-2; MGC26273
Gene ID
51141
UniProt
Q9Y5U4, A0A024RAI2
Accession Number mRNA
NM_016133
Chromosomal Location
2q14.1-q14.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transmembrane
Molecular Weight
24.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
INSIG2
Species
Human
Protein ID
NP_057217
Overview
Recombinant protein of human insulin induced gene 2 (INSIG2)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/51141
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y5U4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016133
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057217
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