RGS7 (NM_002924) Human Recombinant Protein
Product Specifications
Background
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767) . The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509) . May play a role in synaptic vesicle exocytosis (PubMed:12659861) . Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264) .[UniProtKB/Swiss-Prot Function]
Synonyms
OTTHUMP00000037994; regulator of G-protein signaling 7; regulator of G-protein signaling RGS7; regulator of G-protein signalling 7
Gene ID
6000
UniProt
P49802
Accession Number mRNA
NM_002924
Chromosomal Location
1q23.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
56.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RGS7
Species
Human
Protein ID
NP_002915
Overview
Recombinant protein of human regulator of G-protein signaling 7 (RGS7)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6000
Uniprot URL
https://www.uniprot.org/uniprot/P49802
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002924
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002915
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