TJP2 (NM_004817) Human Recombinant Protein
Product Specifications
Background
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Synonyms
C9DUPq21.11; DFNA51; DUP9q21.11; FHCA1; PFIC4; X104; ZO2
Gene ID
9414
UniProt
Q9UDY2, A2A3H9
Accession Number mRNA
NM_004817
Chromosomal Location
9q21.11
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Tight junction, Vibrio cholerae infection
Field of Research
Tight junction, Vibrio cholerae infection
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
133.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TJP2
Species
Human
Protein ID
NP_004808
Overview
Recombinant protein of human tight junction protein 2 (zona occludens 2) (TJP2), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9414
Uniprot URL
https://www.uniprot.org/uniprot/Q9UDY2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004817
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004808
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