TJP2 (NM_004817) Human Recombinant Protein

Product Specifications

Background

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Overview

Recombinant protein of human tight junction protein 2 (zona occludens 2) (TJP2), transcript variant 1

Synonyms

C9DUPq21.11; DFNA51; DUP9q21.11; FHCA1; PFIC4; X104; ZO2

Gene ID

9414

UniProt

Q9UDY2, A2A3H9

Accession Number mRNA

NM_004817

Chromosomal Location

9q21.11

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Tight junction, Vibrio cholerae infection

Field of Research

Tight junction, Vibrio cholerae infection

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

133.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.