GLE1 (NM_001003722) Human Recombinant Protein
Product Specifications
Background
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly (A) +RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly (A) +RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms
CAAHC; CAAHD; GLE1L; hGLE1; LCCS; LCCS1
Gene ID
2733
UniProt
Q53GS7
Accession Number mRNA
NM_001003722
Chromosomal Location
9q34.11
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
79.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GLE1
Species
Human
Protein ID
NP_001003722
Overview
Recombinant protein of human GLE1 RNA export mediator homolog (yeast) (GLE1), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2733
Uniprot URL
https://www.uniprot.org/uniprot/Q53GS7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001003722
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001003722
Curated Selection
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