CYP46 (CYP46A1) (NM_006668) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1)
Synonyms
CP46; CYP46
Gene ID
10858
UniProt
Q9Y6A2
Accession Number mRNA
NM_006668
Chromosomal Location
14q32.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Primary bile acid biosynthesis
Field of Research
Primary bile acid biosynthesis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, P450
Molecular Weight
56.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CYP46A1
Species
Human
Protein ID
NP_006659
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10858
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y6A2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006668
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006659
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