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ATP6V1B2 (NM_001693) Human Recombinant Protein

Selected Variant

PH39354M5

Size: 20 µg

Product Specifications

Background

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (ATP6V1B2)

Synonyms

ATP6B1B2; ATP6B2; DOOD; HO57; VATB; Vma2; VPP3; ZLS2

Gene ID

526

UniProt

P21281, A0A140VK65

Accession Number mRNA

NM_001693

Chromosomal Location

8p21.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Epithelial cell signaling in Helicobacter pylori infection, Metabolic pathways, Oxidative phosphorylation, Vibrio cholerae infection

Field of Research

Epithelial cell signaling in Helicobacter pylori infection, Metabolic pathways, Oxidative phosphorylation, Vibrio cholerae infection

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

56.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ATP6V1B2

Species

Human

Protein ID

NP_001684

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/526

Uniprot URL

https://www.uniprot.org/uniprot/P21281

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001693

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001684

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