SAP18 (NM_005870) Human Recombinant Protein
Product Specifications
Background
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Synonyms
2HOR0202; SAP18P
Gene ID
10284
UniProt
O00422
Accession Number mRNA
NM_005870
Chromosomal Location
13q12.11
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
17.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SAP18
Species
Human
Protein ID
NP_005861
Overview
Recombinant protein of human Sin3A-associated protein, 18kDa (SAP18)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10284
Uniprot URL
https://www.uniprot.org/uniprot/O00422
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005870
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005861
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