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NT5C3 (NT5C3A) (NM_016489) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]

Synonyms

CN-III; hUMP1; NT5C3; P5'N-1; P5N-1; p36; PN-I; POMP; PSN1; UMPH; UMPH1

Gene ID

51251

UniProt

Q9H0P0, A0A024RA81

Accession Number mRNA

NM_016489

Chromosomal Location

7p14.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Nicotinate and nicotinamide metabolism, Purine metabolism, Pyrimidine metabolism

Field of Research

Metabolic pathways, Nicotinate and nicotinamide metabolism, Purine metabolism, Pyrimidine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Transmembrane

Molecular Weight

33.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

NT5C3A

Species

Human

Protein ID

NP_057573

Overview

Recombinant protein of human 5'-nucleotidase, cytosolic III (NT5C3), transcript variant 3

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/51251

Uniprot URL

https://www.uniprot.org/uniprot/Q9H0P0

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_016489

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_057573

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