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Apc6 (CDC16) (NM_003903) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

Overview

Recombinant protein of human cell division cycle 16 homolog (S. cerevisiae) (CDC16), transcript variant 1

Synonyms

ANAPC6; APC6; CDC16Hs; CUT9

Gene ID

8881

UniProt

Q13042, A0A024RDZ2

Accession Number mRNA

NM_003903

Chromosomal Location

13q34

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis

Field of Research

Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

71.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CDC16

Species

Human

Protein ID

NP_003894

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/8881

Uniprot URL

https://www.uniprot.org/uniprot/Q13042

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_003903

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_003894

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