Calpain 2 (CAPN2) (NM_001748) Human Recombinant Protein

Product Specifications

Background

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Overview

Recombinant protein of human calpain 2, (m/II) large subunit (CAPN2)

Synonyms

CANP2; CANPL2; CANPml; mCANP

Gene ID

824

UniProt

P17655, Q59EF6

Accession Number mRNA

NM_001748

Chromosomal Location

1q41

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Alzheimer's disease, Apoptosis, Focal adhesion

Field of Research

Alzheimer's disease, Apoptosis, Focal adhesion

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protease

Molecular Weight

79.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.