Calpain 2 (CAPN2) (NM_001748) Human Recombinant Protein
Product Specifications
Background
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Synonyms
CANP2; CANPL2; CANPml; mCANP
Gene ID
824
UniProt
P17655, Q59EF6
Accession Number mRNA
NM_001748
Chromosomal Location
1q41
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alzheimer's disease, Apoptosis, Focal adhesion
Field of Research
Alzheimer's disease, Apoptosis, Focal adhesion
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protease
Molecular Weight
79.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CAPN2
Species
Human
Protein ID
NP_001739
Overview
Recombinant protein of human calpain 2, (m/II) large subunit (CAPN2)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/824
Uniprot URL
https://www.uniprot.org/uniprot/P17655
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001748
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001739
Curated Selection
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