CYRIB (NM_016623) Human Recombinant Protein

Product Specifications

Background

Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061) . Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061) . Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585) . Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity) . Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164) .[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human family with sequence similarity 49, member B (FAM49B)

Synonyms

BM-009; CYRI; CYRI-B; FAM49B; L1

Gene ID

51571

UniProt

Q9NUQ9, A0A024R9G4

Accession Number mRNA

NM_016623

Chromosomal Location

8q24.21

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

36.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.