SPR (NM_003124) Human Recombinant Protein
Product Specifications
Background
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4) . Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
Synonyms
SDR38C1
Gene ID
6697
UniProt
P35270
Accession Number mRNA
NM_003124
Chromosomal Location
2p13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Folate biosynthesis, Metabolic pathways
Field of Research
Folate biosynthesis, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
27.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SPR
Species
Human
Protein ID
NP_003115
Overview
Recombinant protein of human sepiapterin reductase (7, 8-dihydrobiopterin:NADP+ oxidoreductase) (SPR)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6697
Uniprot URL
https://www.uniprot.org/uniprot/P35270
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003124
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003115
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