SPR (NM_003124) Human Recombinant Protein

Product Specifications

Background

This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4) . Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human sepiapterin reductase (7, 8-dihydrobiopterin:NADP+ oxidoreductase) (SPR)

Synonyms

SDR38C1

Gene ID

6697

UniProt

P35270

Accession Number mRNA

NM_003124

Chromosomal Location

2p13.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Folate biosynthesis, Metabolic pathways

Field of Research

Folate biosynthesis, Metabolic pathways

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

27.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.