SPDEF (NM_012391) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Synonyms
BA375E1.3; PDEF
Gene ID
25803
UniProt
O95238
Accession Number mRNA
NM_012391
Chromosomal Location
6p21.31
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transcription Factors
Molecular Weight
37.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SPDEF
Species
Human
Protein ID
NP_036523
Overview
Recombinant protein of human SAM pointed domain containing ets transcription factor (SPDEF)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/25803
Uniprot URL
https://www.uniprot.org/uniprot/O95238
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_012391
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_036523
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