SH3BP2 (NM_003023) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Overview
Recombinant protein of human SH3-domain binding protein 2 (SH3BP2), transcript variant 1
Synonyms
3BP-2; 3BP2; CRBM; CRPM; RES4-23
Gene ID
6452
UniProt
P78314, A0A384N6E5
Accession Number mRNA
NM_003023
Chromosomal Location
4p16.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Natural killer cell mediated cytotoxicity
Field of Research
Natural killer cell mediated cytotoxicity
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
62.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SH3BP2
Species
Human
Protein ID
NP_003014
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6452
Uniprot URL
https://www.uniprot.org/uniprot/P78314
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003023
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003014
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