TPX2 (NM_012112) Human Recombinant Protein
Product Specifications
Background
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764) . Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764) . TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940) . At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2)
Synonyms
C20orf1; C20orf2; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; p100; REPP86
Gene ID
22974
UniProt
Q9ULW0, Q643R0
Accession Number mRNA
NM_012112
Chromosomal Location
20q11.21
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Stem cell - Pluripotency
Molecular Weight
85.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TPX2
Species
Human
Protein ID
NP_036244
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/22974
Uniprot URL
https://www.uniprot.org/uniprot/Q9ULW0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_012112
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_036244
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