NPL4 (NPLOC4) (NM_017921) Human Recombinant Protein
Product Specifications
Background
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) . Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729) .[UniProtKB/Swiss-Prot Function]
Synonyms
NPL4
Gene ID
55666
UniProt
Q8TAT6, A0A024R8R4
Accession Number mRNA
NM_017921
Chromosomal Location
17q25.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
67.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NPLOC4
Species
Human
Protein ID
NP_060391
Overview
Recombinant protein of human nuclear protein localization 4 homolog (S. cerevisiae) (NPLOC4)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55666
Uniprot URL
https://www.uniprot.org/uniprot/Q8TAT6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_017921
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_060391
Curated Selection
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