BIRC5 (NM_001168) Human Recombinant Protein

Product Specifications

Background

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Overview

Recombinant protein of human baculoviral IAP repeat-containing 5 (BIRC5), transcript variant 1

Synonyms

API4; EPR-1

Gene ID

332

UniProt

O15392, A0A0B4J1S3

Accession Number mRNA

NM_001168

Chromosomal Location

17q25.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Colorectal cancer, Pathways in cancer

Field of Research

Colorectal cancer, Pathways in cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Stem cell - Pluripotency

Molecular Weight

16.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.