TPRKB (NM_016058) Human Recombinant Protein
Product Specifications
Background
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t (6) A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828) . The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828) . TPRKB acts as an allosteric effector that regulates the t (6) A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828) .[UniProtKB/Swiss-Prot Function]
Synonyms
CGI-121; CGI121; GAMOS5
Gene ID
51002
UniProt
Q9Y3C4
Accession Number mRNA
NM_016058
Chromosomal Location
2p13.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
19.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TPRKB
Species
Human
Protein ID
NP_057142
Overview
Recombinant protein of human TP53RK binding protein (TPRKB)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/51002
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y3C4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016058
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057142
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