TPRKB (NM_016058) Human Recombinant Protein

Product Specifications

Background

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t (6) A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828) . The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828) . TPRKB acts as an allosteric effector that regulates the t (6) A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828) .[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human TP53RK binding protein (TPRKB)

Synonyms

CGI-121; CGI121; GAMOS5

Gene ID

51002

UniProt

Q9Y3C4

Accession Number mRNA

NM_016058

Chromosomal Location

2p13.1

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

19.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.