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COX5A (NM_004255) Human Recombinant Protein

Product Specifications

Background

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human cytochrome c oxidase subunit Va (COX5A), nuclear gene encoding mitochondrial protein

Synonyms

COX; COX-VA; MC4DN20; VA

Gene ID

9377

UniProt

P20674

Accession Number mRNA

NM_004255

Chromosomal Location

15q24.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Alzheimer's disease, Cardiac muscle contraction, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Field of Research

Alzheimer's disease, Cardiac muscle contraction, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

12.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

COX5A

Species

Human

Protein ID

NP_004246

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/9377

Uniprot URL

https://www.uniprot.org/uniprot/P20674

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004255

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004246

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