RO60 (NM_001042370) Human Recombinant Protein
Product Specifications
Background
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation (PubMed:18056422) . Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human TROVE domain family, member 2 (TROVE2), transcript variant 3
Synonyms
RORNP; SSA2; TROVE2
Gene ID
6738
UniProt
P10155
Accession Number mRNA
NM_001042370
Chromosomal Location
1q31.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Systemic lupus erythematosus
Field of Research
Systemic lupus erythematosus
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transcription Factors
Molecular Weight
60 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RO60
Species
Human
Protein ID
NP_001035829
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6738
Uniprot URL
https://www.uniprot.org/uniprot/P10155
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001042370
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001035829
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