EGLN2 (NM_053046) Human Recombinant Protein
Product Specifications
Background
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]
Synonyms
EIT-6; EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1
Gene ID
112398
UniProt
Q96KS0, A0A024R0R2
Accession Number mRNA
NM_053046
Chromosomal Location
19q13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Pathways in cancer, Renal cell carcinoma
Field of Research
Pathways in cancer, Renal cell carcinoma
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
26751287
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
43.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EGLN2
Species
Human
Protein ID
NP_444274
Overview
Recombinant protein of human egl nine homolog 2 (C. elegans) (EGLN2), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/112398
Uniprot URL
https://www.uniprot.org/uniprot/Q96KS0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_053046
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_444274
Curated Selection
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