KCTD21 (NM_001029859) Human Recombinant Protein
Product Specifications
Background
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142) .[UniProtKB/Swiss-Prot Function]
Synonyms
KCASH2
Gene ID
283219
UniProt
Q4G0X4
Accession Number mRNA
NM_001029859
Chromosomal Location
11q14.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
29.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KCTD21
Species
Human
Protein ID
NP_001025030
Overview
Recombinant protein of human potassium channel tetramerisation domain containing 21 (KCTD21)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/283219
Uniprot URL
https://www.uniprot.org/uniprot/Q4G0X4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001029859
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001025030
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