EXDL1 (EXD1) (NM_152596) Human Recombinant Protein
Product Specifications
Background
RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity) . The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
EXDL1
Gene ID
161829
UniProt
Q8NHP7
Accession Number mRNA
NM_152596
Chromosomal Location
15q15.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
58.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EXD1
Species
Human
Protein ID
NP_689809
Overview
Recombinant protein of human exonuclease 3'-5' domain containing 1 (EXD1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/161829
Uniprot URL
https://www.uniprot.org/uniprot/Q8NHP7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_152596
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_689809
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