Glutaminase (GLS) (NM_014905) Human Recombinant Protein
Product Specifications
Background
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Synonyms
AAD20; CASGID; DEE71; EIEE71; GAC; GAM; GDPAG; GLS1; KGA
Gene ID
2744
UniProt
O94925
Accession Number mRNA
NM_014905
Chromosomal Location
2q32.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, D-Glutamine and D-glutamate metabolism, Metabolic pathways, Nitrogen metabolism
Field of Research
Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, D-Glutamine and D-glutamate metabolism, Metabolic pathways, Nitrogen metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
73.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GLS
Species
Human
Protein ID
NP_055720
Overview
Recombinant protein of human glutaminase (GLS), nuclear gene encoding mitochondrial protein
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2744
Uniprot URL
https://www.uniprot.org/uniprot/O94925
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014905
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055720
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