MAX (NM_145116) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Overview

Recombinant protein of human MYC associated factor X (MAX), transcript variant 5

Synonyms

BHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; orf1

Gene ID

4149

UniProt

P61244

Accession Number mRNA

NM_145116

Chromosomal Location

14q23.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

MAPK signaling pathway, Pathways in cancer, Small cell lung cancer

Field of Research

MAPK signaling pathway, Pathways in cancer, Small cell lung cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transcription Factors

Molecular Weight

15.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.