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CYP4F12 (NM_023944) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Overview

Recombinant protein of human cytochrome P450, family 4, subfamily F, polypeptide 12 (CYP4F12)

Synonyms

CYPIVF12; F22329_1

Gene ID

66002

UniProt

Q9HCS2

Accession Number mRNA

NM_023944

Chromosomal Location

19p13.12

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, P450, Transmembrane

Molecular Weight

60.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CYP4F12

Species

Human

Protein ID

NP_076433

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/66002

Uniprot URL

https://www.uniprot.org/uniprot/Q9HCS2

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_023944

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_076433

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