ALS (IGFALS) (NM_004970) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Overview
Recombinant protein of human insulin-like growth factor binding protein, acid labile subunit (IGFALS)
Synonyms
ACLSD; ALS
Gene ID
3483
UniProt
P35858, Q8TAY0
Accession Number mRNA
NM_004970
Chromosomal Location
16p13.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
63.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IGFALS
Species
Human
Protein ID
NP_004961
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3483
Uniprot URL
https://www.uniprot.org/uniprot/P35858
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004970
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004961
Curated Selection
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