ASPA (NM_000049) Human Recombinant Protein
Product Specifications
Background
This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human aspartoacylase (Canavan disease) (ASPA), transcript variant 1
Synonyms
ACY2; ASP
Gene ID
443
UniProt
P45381, Q6FH48
Accession Number mRNA
NM_000049
Chromosomal Location
17p13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alanine, aspartate and glutamate metabolism, Histidine metabolism
Field of Research
Alanine, aspartate and glutamate metabolism, Histidine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
35.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ASPA
Species
Human
Protein ID
NP_000040
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/443
Uniprot URL
https://www.uniprot.org/uniprot/P45381
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000049
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000040
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