ARSB (NM_198709) Human Recombinant Protein
Product Specifications
Background
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
Synonyms
ASB; G4S; MPS6
Gene ID
411
UniProt
P15848, A8K4A0
Accession Number mRNA
NM_198709
Chromosomal Location
5q14.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Glycosaminoglycan degradation, Lysosome, Metabolic pathways
Field of Research
Glycosaminoglycan degradation, Lysosome, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
42.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ARSB
Species
Human
Protein ID
NP_942002
Overview
Recombinant protein of human arylsulfatase B (ARSB), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/411
Uniprot URL
https://www.uniprot.org/uniprot/P15848
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_198709
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_942002
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