MAPK11 (NM_002751) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs) . Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Overview
Recombinant protein of human mitogen-activated protein kinase 11 (MAPK11)
Synonyms
P38-2; P38B; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B
Gene ID
5600
UniProt
Q15759
Accession Number mRNA
NM_002751
Chromosomal Location
22q13.33
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway
Field of Research
Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
41.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MAPK11
Species
Human
Protein ID
NP_002742
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5600
Uniprot URL
https://www.uniprot.org/uniprot/Q15759
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002751
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002742
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