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MAPK11 (NM_002751) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs) . Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Overview

Recombinant protein of human mitogen-activated protein kinase 11 (MAPK11)

Synonyms

P38-2; P38B; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B

Gene ID

5600

UniProt

Q15759

Accession Number mRNA

NM_002751

Chromosomal Location

22q13.33

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway

Field of Research

Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protein Kinase

Molecular Weight

41.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

MAPK11

Species

Human

Protein ID

NP_002742

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5600

Uniprot URL

https://www.uniprot.org/uniprot/Q15759

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002751

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002742

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