PDE1B (NM_000924) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Overview
Recombinant protein of human phosphodiesterase 1B, calmodulin-dependent (PDE1B)
Synonyms
HEL-S-79p; PDE1B1; PDES1B
Gene ID
5153
UniProt
Q01064, A0A024RB59
Accession Number mRNA
NM_000924
Chromosomal Location
12q13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism
Field of Research
Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
61.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PDE1B
Species
Human
Protein ID
NP_000915
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5153
Uniprot URL
https://www.uniprot.org/uniprot/Q01064
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000924
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000915
Frequently Asked Questions
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