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Dihydropyrimidinase (DPYS) (NM_001385) Human Recombinant Protein

Product Specifications

Background

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human dihydropyrimidinase (DPYS)

Synonyms

DHP; DHPase

Gene ID

1807

UniProt

Q14117

Accession Number mRNA

NM_001385

Chromosomal Location

8q22.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Beta-Alanine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Pantothenate and CoA biosynthesis, Pyrimidine metabolism

Field of Research

Beta-Alanine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Pantothenate and CoA biosynthesis, Pyrimidine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

56.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

DPYS

Species

Human

Protein ID

NP_001376

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1807

Uniprot URL

https://www.uniprot.org/uniprot/Q14117

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001385

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001376

Frequently Asked Questions

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