Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

E3 SUMO protein ligase PIAS4 (PIAS4) (NM_015897) Human Recombinant Protein

Product Specifications

Background

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.[UniProtKB/Swiss-Prot Function]

Synonyms

PIAS-gamma; Piasg; PIASY; ZMIZ6

Gene ID

51588

UniProt

Q8N2W9, B3KMR4

Accession Number mRNA

NM_015897

Chromosomal Location

19p13.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Jak-STAT signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis

Field of Research

Jak-STAT signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Transcription Factors

Molecular Weight

56.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PIAS4

Species

Human

Protein ID

NP_056981

Overview

Recombinant protein of human protein inhibitor of activated STAT, 4 (PIAS4)

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/51588

Uniprot URL

https://www.uniprot.org/uniprot/Q8N2W9

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_015897

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_056981

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Harringtonolide
MBS5788326 Inquire

Harringtonolide

Ask
View Details
Human AP4B1 knockdown cell line
ABC-KD0764 1 Vial

Human AP4B1 knockdown cell line

Ask
View Details
Apolipoprotein A2 (APOA2) Antibody
abx175422 1 mL

Apolipoprotein A2 (APOA2) Antibody

Ask
View Details
B- and T-lymphocyte attenuator (BTLA) Mouse ELISA Kit
B7657 96 Tests

B- and T-lymphocyte attenuator (BTLA) Mouse ELISA Kit

Ask
View Details