IL10RA (NM_001558) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Overview
Recombinant protein of human interleukin 10 receptor, alpha (IL10RA), transcript variant 1
Synonyms
CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
Gene ID
3587
UniProt
Q13651
Accession Number mRNA
NM_001558
Chromosomal Location
11q23.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
Field of Research
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
60.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IL10RA
Species
Human
Protein ID
NP_001549
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3587
Uniprot URL
https://www.uniprot.org/uniprot/Q13651
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001558
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001549
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