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IMPDH1 (NM_183243) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP) . This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10) . Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Synonyms

IMPD; IMPD1; IMPDH-I; LCA11; RP10; sWSS2608

Gene ID

3614

UniProt

P20839

Accession Number mRNA

NM_183243

Chromosomal Location

7q32.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

Field of Research

Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

60.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

IMPDH1

Species

Human

Protein ID

NP_899066

Overview

Recombinant protein of human IMP (inosine monophosphate) dehydrogenase 1 (IMPDH1), transcript variant 2

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3614

Uniprot URL

https://www.uniprot.org/uniprot/P20839

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_183243

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_899066

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