Cryptochrome I (CRY1) (NM_004075) Human Recombinant Protein
Product Specifications
Background
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
Synonyms
DSPD; PHLL1
Gene ID
1407
UniProt
Q16526, A2I2P0
Accession Number mRNA
NM_004075
Chromosomal Location
12q23.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Circadian rhythm - mammal
Field of Research
Circadian rhythm - mammal
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
66.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CRY1
Species
Human
Protein ID
NP_004066
Overview
Recombinant protein of human cryptochrome 1 (photolyase-like) (CRY1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1407
Uniprot URL
https://www.uniprot.org/uniprot/Q16526
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004075
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004066
Curated Selection
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