GCLM (NM_002061) Human Recombinant Protein
Product Specifications
Background
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Synonyms
GLCLR
Gene ID
2730
UniProt
P48507
Accession Number mRNA
NM_002061
Chromosomal Location
1p22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Glutathione metabolism, Metabolic pathways
Field of Research
Glutathione metabolism, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
30.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GCLM
Species
Human
Protein ID
NP_002052
Overview
Recombinant protein of human glutamate-cysteine ligase, modifier subunit (GCLM)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2730
Uniprot URL
https://www.uniprot.org/uniprot/P48507
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002061
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002052
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