UPP2 (NM_173355) Human Recombinant Protein

Product Specifications

Background

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2 (') -deoxyuridine as substrates.[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human uridine phosphorylase 2 (UPP2), transcript variant 1

Synonyms

UDRPASE2; UP2; UPASE2

Gene ID

151531

UniProt

O95045, A0A0S2Z634

Accession Number mRNA

NM_173355

Chromosomal Location

2q24.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism

Field of Research

Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

35.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.