BID (NM_001196) Human Recombinant Protein
Product Specifications
Background
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8) ; CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]
Synonyms
FP497
Gene ID
637
UniProt
P55957, A8ASI8, B3KT21
Accession Number mRNA
NM_001196
Chromosomal Location
22q11.21
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Pathways in cancer, Viral myocarditis
Field of Research
Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Pathways in cancer, Viral myocarditis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
21.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
BID
Species
Human
Protein ID
NP_001187
Overview
Recombinant protein of human BH3 interacting domain death agonist (BID), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/637
Uniprot URL
https://www.uniprot.org/uniprot/P55957
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001196
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001187
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