DNA Polymerase iota (POLI) (NM_007195) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion. [provided by RefSeq, May 2017]
Overview
Recombinant protein of human polymerase (DNA directed) iota (POLI)
Synonyms
Eta2; RAD3OB; RAD30B
Gene ID
11201
UniProt
Q9UNA4
Accession Number mRNA
NM_007195
Chromosomal Location
18q21.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
82.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
POLI
Species
Human
Protein ID
NP_009126
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/11201
Uniprot URL
https://www.uniprot.org/uniprot/Q9UNA4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_007195
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_009126
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