CIAO1 (NM_004804) Human Recombinant Protein
Product Specifications
Background
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004) . As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004) . Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563) . As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633) .[UniProtKB/Swiss-Prot Function]
Synonyms
CIA1; WDR39
Gene ID
9391
UniProt
O76071
Accession Number mRNA
NM_004804
Chromosomal Location
2q11.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transcription Factors
Molecular Weight
37.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CIAO1
Species
Human
Protein ID
NP_004795
Overview
Recombinant protein of human cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae) (CIAO1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9391
Uniprot URL
https://www.uniprot.org/uniprot/O76071
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004804
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004795
Curated Selection
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