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Beta 2 Microglobulin (B2M) (NM_004048) Human Recombinant Protein

Product Specifications

Background

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

Overview

Recombinant protein of human beta-2-microglobulin (B2M)

Synonyms

IMD43

Gene ID

567

UniProt

P61769

Accession Number mRNA

NM_004048

Chromosomal Location

15q21.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Antigen processing and presentation

Field of Research

Antigen processing and presentation

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Secreted Protein

Molecular Weight

11.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

B2M

Species

Human

Protein ID

NP_004039

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/567

Uniprot URL

https://www.uniprot.org/uniprot/P61769

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004048

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004039

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