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GPNMB (NM_001005340) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human glycoprotein (transmembrane) nmb (GPNMB), transcript variant 1

Synonyms

HGFIN; NMB; PLCA3

Gene ID

10457

UniProt

Q14956

Accession Number mRNA

NM_001005340

Chromosomal Location

7p15.3

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

26751287

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

61.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

GPNMB

Species

Human

Protein ID

NP_001005340

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/10457

Uniprot URL

https://www.uniprot.org/uniprot/Q14956

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001005340

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001005340

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