IKAP (IKBKAP) (NM_003640) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Synonyms
DYS; FD; IKAP; IKBKAP; IKI3; TOT1
Gene ID
8518
UniProt
O95163, Q4LE38, Q8N516
Accession Number mRNA
NM_003640
Chromosomal Location
9q31.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
150.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ELP1
Species
Human
Protein ID
NP_003631
Overview
Recombinant protein of human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8518
Uniprot URL
https://www.uniprot.org/uniprot/O95163
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003640
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003631
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
BNC042894-500 500 µL
Anti-Spectrin beta III (SPTBN2) (SPTBN2/2894R), CF405S conjugate
Ask
View Details